Does PTU affect the pituitary gland?
The results of this study show that while PTU causes a slight increase in pituitary gland weight and in PRL cell numbers, it inhibits estrogen-induced PRL cell hyperplasia. This model can be used to study the effects of PTU on pituitary PRL cell morphology and on the regulation of PRL cell hyperplasia.
What effects does propylthiouracil have?
SIDE EFFECTS: Stomach upset, nausea, vomiting, mild rash/itching, or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
How does propylthiouracil affect the production of thyroxine?
Propylthiouracil is in the antithyroid family of medications. It works by decreasing the amount of thyroid hormone produced by the thyroid gland and blocking the conversion of thyroxine (T4) to triiodothyronine (T3).
How does propylthiouracil for hyperthyroidism work?
Propylthiouracil is in a class of medications called antithyroid agents. It works by stopping the thyroid gland from making thyroid hormone.
What is the most serious potential adverse effect of propylthiouracil?
Agranulocytosis. Agranulocytosis occurs in approximately 0.2% to 0.5% of patients and is a potentially life-threatening side effect of propylthiouracil therapy. Agranulocytosis typically occurs within the first 3 months of therapy.
How long should you take propylthiouracil?
Propylthiouracil should have some effect on your symptoms around three to four weeks after treatment starts. Your thyroid hormone levels should be stabilised within four to eight weeks. Continue to take the tablets for as long as you are advised to do so by your doctor.
How quickly does propylthiouracil work?
What happens when you stop taking PTU?
Effects of Skipping Thyroid Hormone Replacement Blood pressure irregularities. Elevated cholesterol, including treatment-resistant high cholesterol and increased risk of heart disease. Low body temperature; feeling perpetually cold. Fatigue, muscle weakness, or joint pain.